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Table Associations between fasting plasma dicarbonyls and carotid stiffness measures

From: YI 2.3 Methylglyoxal, 3-Deoxyglucosone, and Glyoxal – Precursors of Advanced Glycation Endproducts – are not Independently Associated with Indices of Carotid Stiffness: The Maastricht Study

  

cDC

cRWT

cPWV

cE

Model

 

a (95% CI)

a (95% CI)

a (95% CI)

a (95% CI)

MGO

0

−0.104(−0.145;−0.063)

0.011(−0.030;0.052)

0.103(0.062;0.144)

0.099(0.059;0.140)

 

1

−0.032(−0.070;0.005)

0.010(−0.032;0.052)

0.032(−0.006;0.071)

0.033(−0.007;0.072)

 

2

0.005(−0.029;0.039)

0.000(−0.042;0.042)

−0.004(−0.039;0.030)

−0.006(−0.042;0.030)

 

3

0.003(−0.031;0.037)

0.000(–0. 043; 0.042)

−0.003(−0.038;0.032)

−0.005(−0.040;0.031)

3-DG

0

−0.164(−0.205;−0.123)

0.067(0.026;0.108)

0.149(0.108;0.190)

0.171(0.131;0.212)

 

1

−0.102(−0.154;−0.051)

0.024(–0. 033; 0.082)

0.075(0.023;0.127)

0.093(0.039;0.147)

 

2

−0.037(−0.084;0.009)

0.009(-0.049;0.066)

0.012(−0.036;0.060)

0.027(−0.023;0.076)

 

3

−0.018(−0.065;0.029)

–0. 004(–0.062; 0.054)

−0.007(−0.056;0.041)

0.004(−0.045;0.054)

GO

0

−0.054(−0.095;−0.013)

−0.032(−0.074;0.009)

0.054(0.012;0.095)

0.038(−0.003;0.079)

 

1

−0.015(−0.051;0.022)

–0.014(–0.055; 0.026)

0.015(−0.022;0.052)

0.008(−0.030;0.046)

 

2

0.002(−0.031;0.035)

−0.015(−0.056;0.025)

−0.002(−0.035;0.032)

–0.008(–0. 042;0. 027)

 

3

−0.009(−0.042;0.024)

–0.013(–0.053; 0.028)

0.011(−0.022;0.045)

0.005(−0.030;0.040)

  1. Model 0: crude associations. Model 1: model 0 + age, sex, and glucose metabolism status. Model 2: model 1 + mean arterial pressure and mean heart rate, and anti-hypertensive drugs. Model 3: model 2 + body mass index, smoking status, physical activity, use of lipid-modifying drugs, fasting triglycerides and total-to-high-density lipoprotein cholesterol levels, alcohol use, history of cardiovascular disease, kidney function, and Dutch healthy diet score. MGO, methylglyoxal; 3DG, 3-deoxyglucosone; GO, glyoxal; cDC, carotid distensibility coefficient; cRWT, carotid radius-wall thickness ratio; cPWV, carotid pulse wave velocity; cE, carotid Young’s elastic modulus. Significant associations (p < 0.05) printed in bold.