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YI 2.3 Methylglyoxal, 3-Deoxyglucosone, and Glyoxal – Precursors of Advanced Glycation Endproducts – are not Independently Associated with Indices of Carotid Stiffness: The Maastricht Study

Artery Research volume 26, pages S15–S16 (2020)Cite this article

Abstract

Background

Arterial stiffness is a strong predictor of cardiovascular diseases and all-cause mortality [1]. Increased fasting plasma concentrations of highly reactive dicarbonyl compounds – methylglyoxal (MGO), 3-deoxyglucosone (3-DG), and/or glyoxal (GO) – may cause arterial stiffening via for mation of advanced glycation endproducts, triggering maladaptive responses in vascular tissue, e.g. elastin degradation and collagen cross-linking [2]. We assessed the cross-sectional associations between MGO, 3-DG, and GO concentrations with local carotid stiffness measures (distensibility coefficient (cDC), radius-wall thickness ratio (cRWT), pulse wave velocity (cPWV), and Young’s elastic modulus (cE) using standardized main variables.

Methods

Fasting dicarbonyl concentrations were determined by ultra-performance liquid chromatography tandem mass spectrometry in EDTA plasma collected from 2275 participants (age: 60 ± 8 years, mean ± SD; 49% women, 605 with type 2 diabetes mellitus) of the Maastricht Study [3], an observational, population-based cohort study. Cross-sectional associations were assessed using multivariable linear regression analysis adjusting for age, sex, mean arterial pressure (MAP), heart rate, lifestyle factors, and medication. Since arterial stiffness measures are intrinsically pressure dependent, we additionally assessed the associations with pressure-corrected counterparts [4], instead of statistically correcting for MAP.

Results

Fasting dicarbonyl concentrations were associated with arterial stiffening (smaller cDC; larger cPWV and cE) in most crude models, but not in adjusted models (Table). cRWT was associated with 3-DG, but only in the crude model. The use of pressure-corrected metrics did not materially change the final models.

Conclusion

Fasting plasma concentrations of either MGO, 3-DG, or GO are not independently associated with carotid stiffness in this cross-sectional analysis.

Table Associations between fasting plasma dicarbonyls and carotid stiffness measures
Full size table

References

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  2. Schalkwijk CG, Stehouwer CDA. Methylglyoxal, a highly reactive dicarbonyl compound, in diabetes, its vascular complications, and other age-related diseases. Physiol Rev 2020;100:407–61.

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  3. Schram MT, Sep SJS, van der Kallen CJ, Dagnelie PC, Koster A, Schaper N, et al. The Maastricht study: an extensive phenotyping study on determinants of type 2 diabetes, its complications and its comorbidities. Eur J Epidemiol 2014;29:439–51.

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Authors and Affiliations

  1. CARIM School for Cardiovascular Diseases, Maastricht University, Netherlands

    Myrthe van der Bruggen, Marleen M. J. van Greevenbroek, Koen D. Reesink, Coen D. A. Stehouwer, Tammo Delhaas, Bart Spronck & Casper G. Schalkwijk

  2. Department of Biomedical Engineering, Maastricht University, Netherlands

    Myrthe van der Bruggen, Koen D. Reesink, Tammo Delhaas & Bart Spronck

  3. Department of Internal Medicine, Maastricht University Medical Centre, Netherlands

    Marleen M. J. van Greevenbroek, Coen D. A. Stehouwer & Casper G. Schalkwijk

  4. Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, USA

    Bart Spronck

Authors
  1. Myrthe van der Bruggen
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  2. Marleen M. J. van Greevenbroek
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  3. Koen D. Reesink
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  4. Coen D. A. Stehouwer
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  5. Tammo Delhaas
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  6. Bart Spronck
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  7. Casper G. Schalkwijk
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Corresponding author

Correspondence to Myrthe van der Bruggen.

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This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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van der Bruggen, M., van Greevenbroek, M.M.J., Reesink, K.D. et al. YI 2.3 Methylglyoxal, 3-Deoxyglucosone, and Glyoxal – Precursors of Advanced Glycation Endproducts – are not Independently Associated with Indices of Carotid Stiffness: The Maastricht Study. Artery Res 26 (Suppl 1), S15–S16 (2020). https://doiorg.publicaciones.saludcastillayleon.es/10.2991/artres.k.201209.011

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Keywords

Artery Research

ISSN: 1876-4401

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